Anti-Human SLC31A1 Polyclonal Antibody (HC035014)

Name: Anti-Human SLC31A1 Polyclonal Antibody
Brand: abinScience
SKU: HC035014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HC035014

Description

Anti-Human SLC31A1 Polyclonal Antibody (HC035014) is a rabbit polyclonal antibody detecting High affinity copper uptake protein 1; Copper transporter 1; hCTR1; Solute carrier family 31 member 1; Truncated CTR1 form; SLC31A1; COPT1; CTR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human SLC31A1 (Asp2-Leu61&Tyr83-His132).

Target

High affinity copper uptake protein 1; Copper transporter 1; hCTR1; Solute carrier family 31 member 1; Truncated CTR1 form; SLC31A1; COPT1; CTR1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O15431

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

High affinity copper uptake protein 1 (SLC31A1) is a ~21 kDa protein. Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels. May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption. The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity. Also mediates the uptake of silver(1+). May function in the influx of the platinum-containing chemotherapeutic agents.

1. Lee, J. et al. (2002) The Journal of biological chemistry 277, 4380-7. PMID: 11734551

2. Eisses, JF. et al. (2005) The Journal of biological chemistry 280, 37159-68. PMID: 16135512

3. Maryon, EB. et al. (2007) The Journal of biological chemistry 282, 20376-87. PMID: 17525160

4. Molloy, SA. et al. (2009) The Journal of biological chemistry 284, 29704-13. PMID: 19740744

5. Larson, CA. et al. (2010) Biochemical pharmacology 80, 448-54. PMID: 20451502

6. Bertinato, J. et al. (2010) Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 24, 178-84. PMID: 20569931

7. Maryon, EB. et al. (2013) The Journal of biological chemistry 288, 18035-46. PMID: 23658018

Note

For research use only

Images

References

Datasheet

Anti-Human SLC31A1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SLC31A1 Polyclonal Antibody (HC035014)

Overview

Images

References

Datasheet

SDS

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