Anti-Human SLC5A8 Polyclonal Antibody (HP275014)

Name: Anti-Human SLC5A8 Polyclonal Antibody
Brand: abinScience
SKU: HP275014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP275014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SLC5A8 (Ala460-Ser520).

Target

Apical iodide transporter, Sodium-coupled monocarboxylate transporter 1, SMCT1, AIT, Sodium iodide-related cotransporter, SMCT, Solute carrier family 5 member 8, Electrogenic sodium monocarboxylate cotransporter, SLC5A8

Purification

Purified by antigen affinity column.

Accession

Q8N695

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sodium-coupled monocarboxylate transporter 1 (SLC5A8) is a ~66 kDa protein. Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines.

1. Miyauchi, S. et al. (2004) The Journal of biological chemistry 279, 13293-6. PMID: 14966140

2. Coady, MJ. et al. (2004) The Journal of physiology 557, 719-31. PMID: 15090606

3. Itagaki, S. et al. (2006) Pharmaceutical research 23, 1209-16. PMID: 16729224

4. Martin, PM. et al. (2006) Journal of neurochemistry 98, 279-88. PMID: 16805814

5. Thangaraju, M. et al. (2006) Cancer research 66, 11560-4. PMID: 17178845

6. Gopal, E. et al. (2007) Pharmaceutical research 24, 575-84. PMID: 17245649

7. Coady, MJ. et al. (2007) Biophysical journal 93, 2325-31. PMID: 17526579

8. Miyauchi, S. et al. (2010) Biochimica et biophysica acta 1798, 1164-71. PMID: 20211600

9. Srivastava, S. et al. (2019) The journal of physiological sciences : JPS 69, 399-408. PMID: 30604288

10. Rodriguez, AM. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3500-3. PMID: 12107270

Note

For research use only.

Images

References

Datasheet

Anti-Human SLC5A8 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SLC5A8 Polyclonal Antibody (HP275014)

Overview

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Datasheet

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