Anti-Human SLCO1A2 Polyclonal Antibody (HW453014)

Name: Anti-Human SLCO1A2 Polyclonal Antibody
Brand: abinScience
SKU: HW453014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HW453014

Description

Anti-Human SLCO1A2 Polyclonal Antibody (HW453014) is a rabbit polyclonal antibody detecting SLCO1A2. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SLCO1A2 (Phe406-Phe513).

Target

OATP, OATP-1, OATP-A, OATP1, OATP1A2, Organic anion-transporting polypeptide 1, SLC21A3, SLCO1A2, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, Solute carrier organic anion transporter family member 1A2

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P46721

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Solute carrier organic anion transporter family member 1A2 (SLCO1A2) is a ~74 kDa protein. Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids. Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs.

1. Leuthold, S. et al. (2009) American journal of physiology. Cell physiology 296, C570-82. PMID: 19129463

2. Kullak-Ublick, GA. et al. (1995) Gastroenterology 109, 1274-82. PMID: 7557095

3. Kullak-Ublick, GA. et al. (2001) Gastroenterology 120, 525-33. PMID: 11159893

4. Briz, O. et al. (2003) The Biochemical journal 371, 897-905. PMID: 12568656

5. Zhou, F. et al. (2013) The AAPS journal 15, 1099-108. PMID: 23918469

6. Chan, T. et al. (2015) British journal of pharmacology 172, 2343-53. PMID: 25560245

7. Kullak-Ublick, GA. et al. (1998) FEBS letters 424, 173-6. PMID: 9539145

8. Bailey, DG. et al. (2007) Clinical pharmacology and therapeutics 81, 495-502. PMID: 17301733

Note

For research use only

Images

References

Datasheet

Anti-Human SLCO1A2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SLCO1A2 Polyclonal Antibody (HW453014)

Overview

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Datasheet

SDS

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