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Anti-Human SMPDL3B Polyclonal Antibody (HD667014)

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Overview
Catalog No.HD667014
Description
Anti-Human SMPDL3B Polyclonal Antibody (HD667014) is a rabbit polyclonal antibody detecting SMPDL3B. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SMPDL3B (Gly21-Gly433).
Target ASM-like phosphodiesterase 3b, ASML3B, ASMLPD, Acid sphingomyelinase-like phosphodiesterase 3b, EC:3.1.4.-, SMPDL3B
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q92485
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) is a ~50 kDa protein. Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro).

1. Heinz, LX. et al. (2015) Cell reports 11, 1919-28. PMID: 26095358
Note For research use only
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Formula
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Anti-Human SMPDL3B Polyclonal Antibody

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