Anti-Human SNX1 Polyclonal Antibody (HC628014)

Name: Anti-Human SNX1 Polyclonal Antibody
Brand: abinScience
SKU: HC628014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC628014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SNX1 (Phe143-Ser522).

Target

Sorting nexin-1, SNX1

Purification

Purified by antigen affinity column.

Accession

Q13596

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sorting nexin-1 (SNX1) is a ~59 kDa protein. Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).

1. Cozier, GE. et al. (2002) The Journal of biological chemistry 277, 48730-6. PMID: 12198132

2. Bhatia, VK. et al. (2009) The EMBO journal 28, 3303-14. PMID: 19816406

3. van Weering, JR. et al. (2012) The EMBO journal 31, 4466-80. PMID: 23085988

4. Carlton, J. et al. (2004) Current biology : CB 14, 1791-800. PMID: 15498486

5. Rojas, R. et al. (2007) Molecular and cellular biology 27, 1112-24. PMID: 17101778

6. Bujny, MV. et al. (2007) Journal of cell science 120, 2010-21. PMID: 17550970

7. Mari, M. et al. (2008) Traffic (Copenhagen, Denmark) 9, 380-93. PMID: 18088323

8. Kim, E. et al. (2010) Biochemical and biophysical research communications 403, 167-71. PMID: 21040701

9. Gullapalli, A. et al. (2006) Molecular biology of the cell 17, 1228-38. PMID: 16407403

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SNX1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: U87 cell lysate
Lane 2: DU145 cell lysate

References

Datasheet

Anti-Human SNX1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human SNX1 Polyclonal Antibody (HC628014)

Overview

Images

References

Datasheet

SDS

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