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Anti-Human SNX17 Polyclonal Antibody (HC387014)

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Overview
Catalog No.HC387014
Description
Anti-Human SNX17 Polyclonal Antibody (HC387014) is a rabbit polyclonal antibody detecting SNX17 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SNX17 (Met1-Gly401).
Target KIAA0064, SNX17, Sorting nexin-17
Purification Purified by antigen affinity column.
Accession Q15036
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Sorting nexin-17 (SNX17) is a ~52 kDa protein. Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

1. Williams, R. et al. (2004) Molecular biology of the cell 15, 3095-105. PMID: 15121882
2. Knauth, P. et al. (2005) Journal of molecular biology 347, 813-25. PMID: 15769472
3. Singla, A. et al. (2024) Nature communications 15, 10193. PMID: 39587083
4. Ghai, R. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7763-8. PMID: 21512128
5. Steinberg, F. et al. (2012) The Journal of cell biology 197, 219-30. PMID: 22492727
6. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079
7. Czubayko, M. et al. (2006) Biochemical and biophysical research communications 345, 1264-72. PMID: 16712798
8. Donoso, M. et al. (2009) Molecular biology of the cell 20, 481-97. PMID: 19005208
Note For research use only.
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Datasheet
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Formula
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Anti-Human SNX17 Polyclonal Antibody

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