Anti-Human SOCS1 Polyclonal Antibody (HT384014)

Name: Anti-Human SOCS1 Polyclonal Antibody
Brand: abinScience
SKU: HT384014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT384014

Description

Anti-Human SOCS1 Polyclonal Antibody (HT384014) is a rabbit polyclonal antibody detecting SOCS1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SOCS1 (Ser60-Ile211).

Target

SOCS-1, SSI-1, JAB, JAK-binding protein, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, Tec-interacting protein 3, TIP-3, SSI1, SOCS1, TIP3

Purification

Purified by antigen affinity column.

Accession

O15524

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Suppressor of cytokine signaling 1 (SOCS1) is a ~23 kDa protein. Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival.

1. Thaventhiran, JED. et al. (2020) Nature 583, 90-95. PMID: 32499645

2. Hadjadj, J. et al. (2020) Nature communications 11, 5341. PMID: 33087723

3. Ohya, Ki. et al. (1997) The Journal of biological chemistry 272, 27178-82. PMID: 9341160

4. Kamizono, S. et al. (2001) The Journal of biological chemistry 276, 12530-8. PMID: 11278610

5. Frantsve, J. et al. (2001) Molecular and cellular biology 21, 3547-57. PMID: 11313480

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SOCS1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: Hepg2 cell lysate
Lane 3: A549 cell lysate
Lane 4: Mouse spleen lysate

References

Datasheet

Anti-Human SOCS1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human SOCS1 Polyclonal Antibody (HT384014)

Overview

Images

References

Datasheet

SDS

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