Anti-Human SUCLA2 Polyclonal Antibody (HP689014)

Name: Anti-Human SUCLA2 Polyclonal Antibody
Brand: abinScience
SKU: HP689014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HP689014

Description

Anti-Human SUCLA2 Polyclonal Antibody (HP689014) is a rabbit polyclonal antibody detecting SUCLA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Columba livia, and Macaca fascicularis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SUCLA2 (Ser54-Glu445).

Target

ATP-specific succinyl-CoA synthetase subunit beta, SCS-betaA, Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, A-SCS, Succinyl-CoA synthetase beta-A chain, SUCLA2

Purification

Purified by antigen affinity column.

Accession

Q9P2R7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) is a ~50 kDa protein. ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase.

1. Elpeleg, O. et al. (2005) American journal of human genetics 76, 1081-6. PMID: 15877282

2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704

3. Griffith, CM. et al. (2025) Nature chemical biology 21, 906-915. PMID: 40108300

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SUCLA2 polyclonal antibody at 1μg/ml on various samples.
Lane 1: SH-SY5Y cell lysate
Lane 2: HepG2 cell lysate
Lane 3: PC3 cell lysate
Lane 4: LO2 cell lysate
Lane 5: Hela cell lysate
Lane 6: 293T cell lysate
Lane 7: Mouse brain lysate
Lane 8: Mouse liver lysate
Lane 9: Mouse heart lysate
Lane 10: Mouse spleen lysate
Lane11: Rat brain lysate
Lane12: Rat liver lysate
Lane13: Rat heart lysate
Lane14: Rat spleen lysate

References

Datasheet

Anti-Human SUCLA2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SUCLA2 Polyclonal Antibody (HP689014)

Overview

Images

References

Datasheet

SDS

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