Anti-Human SUGCT Polyclonal Antibody (HA129014)

Name: Anti-Human SUGCT Polyclonal Antibody
Brand: abinScience
SKU: HA129014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA129014

Description

Anti-Human SUGCT Polyclonal Antibody (HA129014) is a rabbit polyclonal antibody detecting SUGCT in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SUGCT (Gln32-His438).

Target

Succinate--hydroxymethylglutarate CoA-transferase, 2.8.3.13, Dermal papilla-derived protein 13, SuccinylCoA:glutarate-CoA transferase, SUGCT, C7orf10, DERP13

Purification

Purified by antigen affinity column.

Accession

Q9HAC7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Succinyl-CoA:glutarate CoA-transferase (SUGCT) is a ~47 kDa protein. Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.

1. Marlaire, S. et al. (2014) Journal of inherited metabolic disease 37, 13-9. PMID: 23893049

2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704

3. Wu, R. et al. (2024) ACS chemical biology 19, 1544-1553. PMID: 38915184

4. Sherman, EA. et al. (2008) American journal of human genetics 83, 604-9. PMID: 18926513

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SYGCT polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse kidney lysate

References

Datasheet

Anti-Human SUGCT Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SUGCT Polyclonal Antibody (HA129014)

Overview

Images

References

Datasheet

SDS

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