Anti-Human SUZ12 Polyclonal Antibody (HC259014)

Name: Anti-Human SUZ12 Polyclonal Antibody
Brand: abinScience
SKU: HC259014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HC259014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SUZ12 (Lys587-Gly691).

Target

SUZ12, Polycomb protein SUZ12, Joined to JAZF1 protein, CHET9, KIAA0160, ChET 9 protein, Suppressor of zeste 12 protein homolog, Chromatin precipitated E2F target 9 protein, JJAZ1

Purification

Purified by antigen affinity column.

Accession

Q15022

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Polycomb protein SUZ12 is a ~83 kDa protein. Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

1. Cao, R. et al. (2004) Molecular cell 15, 57-67. PMID: 15225548

2. Kirmizis, A. et al. (2004) Genes & development 18, 1592-605. PMID: 15231737

3. Pasini, D. et al. (2004) The EMBO journal 23, 4061-71. PMID: 15385962

4. Bracken, AP. et al. (2006) Genes & development 20, 1123-36. PMID: 16618801

5. Bracken, AP. et al. (2007) Genes & development 21, 525-30. PMID: 17344414

6. Sarma, K. et al. (2008) Molecular and cellular biology 28, 2718-31. PMID: 18285464

7. Imagawa, E. et al. (2017) Human mutation 38, 637-648. PMID: 28229514

8. Chen, S. et al. (2018) Molecular cell 69, 840-852.e5. PMID: 29499137

9. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557

10. Cao, R. et al. (2002) Science (New York, N.Y.) 298, 1039-43. PMID: 12351676

Note

For research use only.

Images

References

Datasheet

Anti-Human SUZ12 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human SUZ12 Polyclonal Antibody (HC259014)

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Datasheet

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