

| Catalog No. | HA154014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human THAP1 Polyclonal Antibody (HA154014) is a rabbit polyclonal antibody detecting THAP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Species reactivity | Human, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human THAP1 (Ser21-Glu66). | ||||||||
| Target | THAP domain-containing protein 1, THAP1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q9NVV9 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | THAP domain-containing protein 1 (THAP1) is a ~24 kDa protein. DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. | ||||||||
| Note | For research use only. |
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