Anti-Human TICAM1 Polyclonal Antibody (HV815014)

Name: Anti-Human TICAM1 Polyclonal Antibody
Brand: abinScience
SKU: HV815014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HV815014

Description

Anti-Human TICAM1 Polyclonal Antibody (HV815014) is a rabbit polyclonal antibody detecting TICAM1. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TICAM1 (Met1-Cys144).

Target

MyD88-3, PRVTIRB, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TICAM1, TIR domain-containing adapter molecule 1, TIR domain-containing adapter protein inducing IFN-beta, TRIF, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q8IUC6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

TIR domain-containing adapter molecule 1 (TICAM1) is a ~76 kDa protein. Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens.

1. Yamamoto, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 6668-72. PMID: 12471095

2. Oshiumi, H. et al. (2003) Nature immunology 4, 161-7. PMID: 12539043

3. Han, KJ. et al. (2004) The Journal of biological chemistry 279, 15652-61. PMID: 14739303

4. Ye, W. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 1856-1864. PMID: 28747347

5. Pallett, MA. et al. (2022) Viruses 14. PMID: 35215908

6. Liu, S. et al. (2015) Science (New York, N.Y.) 347, aaa2630. PMID: 25636800

Note

For research use only

Images

Western blot

Lane 1: Raji cell lysate

References

Datasheet

Anti-Human TICAM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TICAM1 Polyclonal Antibody (HV815014)

Overview

Images

References

Datasheet

SDS

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