Anti-Human TMEM97 Polyclonal Antibody (HS768014)

Name: Anti-Human TMEM97 Polyclonal Antibody
Brand: abinScience
SKU: HS768014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HS768014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human TMEM97 (Gln31-Ser68).

Target

Sigma-2 receptor, Sigma intracellular receptor 2, Meningioma-associated protein 30, MAC30, Transmembrane protein 97, S2R, TMEM97, Sigma2 receptor

Purification

Purified by antigen affinity column.

Accession

Q5BJF2

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sigma intracellular receptor 2 (TMEM97) is a ~20 kDa protein. Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface (Probable). Forms a ternary complex with PGRMC1 receptor and low density lipoprotein receptor/LDLR at the plasma membrane, which increases LDLR-mediated LDL cholesterol internalization. Decreases lysosomal sterol transporter NPC1 availability to the cell, probably through NPC1-binding, hence controlling lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome. Binds regio- and stereoselective ligand 20(S)-hydroxycholesterol (20(S)-OHC) which enhances TMEM97-NPC1 interaction and decreases TMEM97-PGRMC1 and TMEM97-TSPO interactions, thereby linking OHC binding to cholesterol homeostasis. Also able to bind cholesterol.

1. Bartz, F. et al. (2009) Cell metabolism 10, 63-75. PMID: 19583955

2. Huang, YS. et al. (2014) Medicinal research reviews 34, 532-66. PMID: 23922215

3. Guo, L. et al. (2015) Current medicinal chemistry 22, 989-1003. PMID: 25620095

4. Ebrahimi-Fakhari, D. et al. (2016) Human molecular genetics 25, 3588-3599. PMID: 27378690

5. Alon, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 7160-7165. PMID: 28559337

6. Riad, A. et al. (2018) Scientific reports 8, 16845. PMID: 30443021

7. Son, KN. et al. (2021) The FEBS journal 288, 6815-6827. PMID: 34233061

8. Cheng, YS. et al. (2021) Nature chemical biology 17, 1271-1280. PMID: 34799735

9. Ma, D. et al. (2022) International journal of oral science 14, 42. PMID: 35970844

Note

For research use only.

Images

References

Datasheet

Anti-Human TMEM97 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TMEM97 Polyclonal Antibody (HS768014)

Overview

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