Anti-Human TOMM22 Polyclonal Antibody (HP793014)

Name: Anti-Human TOMM22 Polyclonal Antibody
Brand: abinScience
SKU: HP793014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP793014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human TOMM22 (Glu42-Ala84).

Target

1C9-2, TOM22, Translocase of outer membrane 22 kDa subunit homolog, hTom22, Mitochondrial import receptor subunit TOM22 homolog, TOMM22

Purification

Purified by antigen affinity column.

Accession

Q9NS69

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Mitochondrial import receptor subunit TOM22 homolog (TOMM22) is a ~15 kDa protein. Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.

1. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546

2. Yano, M. et al. (2000) Molecular and cellular biology 20, 7205-13. PMID: 10982837

Note

For research use only.

Images

References

Datasheet

Anti-Human TOMM22 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TOMM22 Polyclonal Antibody (HP793014)

Overview

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References

Datasheet

SDS

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