Anti-Human TP53I3 Polyclonal Antibody (HD613014)

Name: Anti-Human TP53I3 Polyclonal Antibody
Brand: abinScience
SKU: HD613014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HD613014

Description

Anti-Human TP53I3 Polyclonal Antibody (HD613014) is a rabbit polyclonal antibody detecting TP53I3. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TP53I3 (Met1-Gln332).

Target

EC:1.6.5.5, NADPH:quinone reductase PIG3, PIG3, Protein PIG3, Quinone oxidoreductase PIG3, TP53I3, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q53FA7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Quinone oxidoreductase PIG3 (TP53I3) is a ~35 kDa protein. NADPH:quinone reductase which expression is induced by p53/TP53 and is involved in both the DNA damage response through homologous recombination repair, and p53-mediated apoptosis. Catalyzes the NADPH-dependent reduction of quinones, exhibiting a low enzymatic activity with beta-naphthoquinones and a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro). The reduction of 1,2-naphthoquinone concurrently generates reactive oxygen species (ROS), which may trigger apoptosis downstream of p53/TP53.

1. Porté, S. et al. (2009) The Journal of biological chemistry 284, 17194-17205. PMID: 19349281

2. Chaudhry, SR. et al. (2021) Cell death discovery 7, 62. PMID: 33782397

Note

For research use only

Images

References

Datasheet

Anti-Human TP53I3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TP53I3 Polyclonal Antibody (HD613014)

Overview

Images

References

Datasheet

SDS

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