Human TP53I3 Recombinant Protein (N-His) (HD613012)

Name: Human TP53I3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD613012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD613012
Description	Recombinant Human TP53I3 Protein, N-His (HD613012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q53FA7
Protein length	Met1-Gln332
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:1.6.5.5, NADPH:quinone reductase PIG3, PIG3, Protein PIG3, Quinone oxidoreductase PIG3, TP53I3, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein
Background	Quinone oxidoreductase PIG3 is a ~35 kDa protein. NADPH:quinone reductase which expression is induced by p53/TP53 and is involved in both the DNA damage response through homologous recombination repair, and p53-mediated apoptosis. Catalyzes the NADPH-dependent reduction of quinones, exhibiting a low enzymatic activity with beta-naphthoquinones and a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro). The reduction of 1,2-naphthoquinone concurrently generates reactive oxygen species (ROS), which may trigger apoptosis downstream of p53/TP53. 1. Porté, S. et al. (2009) The Journal of biological chemistry 284, 17194-17205. PMID: 19349281 2. Chaudhry, SR. et al. (2021) Cell death discovery 7, 62. PMID: 33782397
Note	For research use only

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Datasheet

Human TP53I3 Recombinant Protein (N-His).pdf

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Human TP53I3 Recombinant Protein (N-His) (HD613012)

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