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Anti-Human TREX1 Polyclonal Antibody (HV590024)

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Overview
Catalog No.HV590024
Description
Anti-Human TREX1 Polyclonal Antibody (HV590024) is a rabbit polyclonal antibody detecting TREX1. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human TREX1 (Met11-His222).
Target 3'-5' exonuclease TREX1, DNase III, Deoxyribonuclease III, EC:3.1.11.2, TREX1, Three-prime repair exonuclease 1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9NSU2
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904
2. Höss, M. et al. (1999) The EMBO journal 18, 3868-75. PMID: 10393201
3. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595
4. Mohr, L. et al. (2021) Molecular cell 81, 724-738.e9. PMID: 33476576
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human TREX1 Polyclonal Antibody

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