Anti-Human TRIM14 Polyclonal Antibody (HC308014)

Name: Anti-Human TRIM14 Polyclonal Antibody
Brand: abinScience
SKU: HC308014
Price: 168 USD
Availability: InStock

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Datasheet
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Overview

Catalog No.

HC308014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human TRIM14 (Ser254-Pro442).

Target

KIAA0129, Tripartite motif-containing protein 14, TRIM14

Purification

Purified by antigen affinity column.

Accession

Q14142

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tripartite motif-containing protein 14 (TRIM14) is a ~49 kDa protein. Plays an essential role in the innate immune defense against viruses and bacteria. Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication. Also plays a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation.

1. Tan, G. et al. (2018) Frontiers in immunology 9, 1872. PMID: 30150992

2. Hoffpauir, CT. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 153-167. PMID: 32404352

3. Wang, S. et al. (2016) Scientific reports 6, 32336. PMID: 27578425

4. Kuroda, M. et al. (2023) The Journal of infectious diseases 228, S514-S521. PMID: 37562033

5. Zhou, Z. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E245-54. PMID: 24379373

6. Chen, M. et al. (2016) Molecular cell 64, 105-119. PMID: 27666593

7. Liu, D. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35145029

Note

For research use only.

Images

References

Datasheet

Anti-Human TRIM14 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TRIM14 Polyclonal Antibody (HC308014)

Overview

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References

Datasheet

SDS

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