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Anti-Human TRIM27 Polyclonal Antibody (HB027014)

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Overview
Catalog No.HB027014
Description
Anti-Human TRIM27 Polyclonal Antibody (HB027014) is a rabbit polyclonal antibody detecting TRIM27 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human TRIM27 (Ser315-Pro513).
Target RING finger protein 76, Zinc finger protein RFP, RFP, TRIM27, RNF76, RING-type E3 ubiquitin transferase TRIM27, Tripartite motif-containing protein 27, Ret finger protein
Purification Purified by antigen affinity column.
Accession P14373
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Zinc finger protein RFP (TRIM27) is a ~58 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events.

1. Zurek, B. et al. (2012) PloS one 7, e41255. PMID: 22829933
2. Zaman, MM. et al. (2013) Molecular and cellular biology 33, 4971-84. PMID: 24144979
3. Cai, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 5238-5249. PMID: 29688809
4. Garcia-Garcia, J. et al. (2023) The FEBS journal 290, 1096-1116. PMID: 36111389
5. Hao, YH. et al. (2013) Cell 152, 1051-64. PMID: 23452853
6. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190
Note For research use only.
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Datasheet
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Formula
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Anti-Human TRIM27 Polyclonal Antibody

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