Anti-Human TRIM33 Polyclonal Antibody (HP145014)

Name: Anti-Human TRIM33 Polyclonal Antibody
Brand: abinScience
SKU: HP145014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HP145014

Description

Anti-Human TRIM33 Polyclonal Antibody (HP145014) is a rabbit polyclonal antibody detecting TRIM33 in ELISA, IHC, WB. Suitable for Human, Mouse, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TRIM33 (Asp882-Ala1087).

Target

TRIM33, RFG7, KIAA1113, RET-fused gene 7 protein, Tripartite motif-containing protein 33, RING-type E3 ubiquitin transferase TRIM33, E3 ubiquitin-protein ligase TRIM33, Protein Rfg7, TIF1-gamma, Ectodermin homolog, TIF1G, Transcription intermediary factor 1-gamma

Purification

Purified by antigen affinity column.

Accession

Q9UPN9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

E3 ubiquitin-protein ligase TRIM33 is a ~122 kDa protein. Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade.

1. He, W. et al. (2006) Cell 125, 929-41. PMID: 16751102

Note

For research use only.

Images

References

Datasheet