Anti-Human TRPM2 Polyclonal Antibody (HA519014)

Name: Anti-Human TRPM2 Polyclonal Antibody
Brand: abinScience
SKU: HA519014
Price: 96 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HA519014

Description

Anti-Human TRPM2 Polyclonal Antibody (HA519014) is a rabbit polyclonal antibody detecting TRPM2 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human TRPM2 (Lys140-Arg358).

Target

TRPM2

Purification

Purified by antigen affinity column.

Accession

O94759

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

Transient receptor potential cation channel subfamily M member 2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7, Transient receptor potential melastatin 2, TRPM2, EREG1, KNP3, LTRPC2, TRPC7

Background

Transient receptor potential cation channel subfamily M member 2 (TRPM2) is a ~171 kDa protein. Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress. The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular Ca(2+) passes through the channel and increases channel activity.

1. Perraud, AL. et al. (2001) Nature 411, 595-9. PMID: 11385575

2. Sano, Y. et al. (2001) Science (New York, N.Y.) 293, 1327-30. PMID: 11509734

3. Hara, Y. et al. (2002) Molecular cell 9, 163-73. PMID: 11804595

4. Zhang, W. et al. (2003) The Journal of biological chemistry 278, 16222-9. PMID: 12594222

5. Perraud, AL. et al. (2005) The Journal of biological chemistry 280, 6138-48. PMID: 15561722

6. Togashi, K. et al. (2006) The EMBO journal 25, 1804-15. PMID: 16601673

7. Csanády, L. et al. (2009) The Journal of general physiology 133, 189-203. PMID: 19171771

8. Yang, W. et al. (2010) The Journal of biological chemistry 285, 30411-8. PMID: 20660597

9. Kühn, FJ. et al. (2015) Scientific reports 5, 8032. PMID: 25620041

10. Li, F. et al. (2016) Journal of cell science 129, 2016-29. PMID: 27068538

Note

For research use only.

Images

References

Datasheet

Anti-Human TRPM2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human TRPM2 Polyclonal Antibody (HA519014)

Overview

Images

References

Datasheet

SDS

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