Anti-Human TRPV6/ECaC2 Polyclonal Antibody (HP583014)

Name: Anti-Human TRPV6/ECaC2 Polyclonal Antibody
Brand: abinScience
SKU: HP583014
Price: 168 USD
Availability: InStock

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References
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SDS

Overview

Catalog No.

HP583014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TRPV6/ECaC2 (Ser87-Asp319).

Target

CaT1, Transient receptor potential cation channel subfamily V member 6, CaT-like, TrpV6, CaT-L, ECAC2, TRPV6, ECaC2, Epithelial calcium channel 2, Calcium transport protein 1

Purification

Purified by antigen affinity column.

Accession

Q9H1D0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Transient receptor potential cation channel subfamily V member 6 (TRPV6/ECaC2) is a ~87 kDa protein. Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner.

1. Peng, JB. et al. (2000) Biochemical and biophysical research communications 278, 326-32. PMID: 11097838

2. Niemeyer, BA. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 3600-5. PMID: 11248124

3. Wissenbach, U. et al. (2001) The Journal of biological chemistry 276, 19461-8. PMID: 11278579

4. Bödding, M. et al. (2004) The Journal of biological chemistry 279, 36546-52. PMID: 15184369

5. Fecher-Trost, C. et al. (2013) The Journal of biological chemistry 288, 16629-16644. PMID: 23612980

6. McGoldrick, LL. et al. (2018) Nature 553, 233-237. PMID: 29258289

Note

For research use only.

Images

References

Datasheet

Anti-Human TRPV6/ECaC2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TRPV6/ECaC2 Polyclonal Antibody (HP583014)

Overview

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References

Datasheet

SDS

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