

| Catalog No. | HC200014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human TUT7 Polyclonal Antibody (HC200014) is a rabbit polyclonal antibody detecting TUT7. Suitable for Human and Mouse.
Highlights
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| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human TUT7 (Lys996-Arg1379). | ||||||||
| Target | EC:2.7.7.52, HS2, KIAA1711, TUT7, TUTase 7, Terminal uridylyltransferase 7, ZCCHC6, Zinc finger CCHC domain-containing protein 6 | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q5VYS8 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Background | Terminal uridylyltransferase 7 (TUT7) is a ~171 kDa protein. Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms. 1. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396 2. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299 3. Kim, B. et al. (2015) The EMBO journal 34, 1801-15. PMID: 25979828 4. Thornton, JE. et al. (2012) RNA (New York, N.Y.) 18, 1875-85. PMID: 22898984 5. Faehnle, CR. et al. (2017) Nature structural & molecular biology 24, 658-665. PMID: 28671666 6. Mullen, TE. et al. (2008) Genes & development 22, 50-65. PMID: 18172165 | ||||||||
| Note | For research use only |
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