Anti-Human UBQLN4 Polyclonal Antibody (HP715014)

Name: Anti-Human UBQLN4 Polyclonal Antibody
Brand: abinScience
SKU: HP715014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HP715014

Description

Anti-Human UBQLN4 Polyclonal Antibody (HP715014) is a rabbit polyclonal antibody detecting Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75; UBQLN4; C1orf6; CIP75; UBIN. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human UBQLN4 (Pro12-Lys83).

Target

Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75; UBQLN4; C1orf6; CIP75; UBIN

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9NRR5

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Ubiquilin-4 (UBQLN4) is a ~63 kDa protein. Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation.

1. Riley, BE. et al. (2004) The Journal of biological chemistry 279, 42290-301. PMID: 15280365

2. Suzuki, R. et al. (2016) EMBO reports 17, 842-57. PMID: 27113755

3. Hirayama, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E4199-E4208. PMID: 29666234

4. Jachimowicz, RD. et al. (2019) Cell 176, 505-519.e22. PMID: 30612738

5. Lee, DY. et al. (2013) EMBO reports 14, 373-81. PMID: 23459205

Note

For research use only

Images

Western blot

Lane 1: Hela cell lysate
Lane 2: 293T cell lysate
Lane 3: MCF-7 cell lysate
Lane 4: K562 cell lysate

References

Datasheet

Anti-Human UBQLN4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human UBQLN4 Polyclonal Antibody (HP715014)

Overview

Images

References

Datasheet

SDS

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