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Anti-Human UFD1 Polyclonal Antibody (HP550014)

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Overview
Catalog No.HP550014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human UFD1 (Arg18-Asp192).
Target UFD1L, Ubiquitin recognition factor in ER-associated degradation protein 1, UB fusion protein 1, UFD1, Ubiquitin fusion degradation protein 1
Purification Purified by antigen affinity column.
Accession Q92890
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1) is a ~34 kDa protein. Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.

1. Hao, Q. et al. (2015) The EMBO journal 34, 2903-20. PMID: 26471729
Note For research use only.
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Anti-Human UFD1 Polyclonal Antibody

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