Anti-Human USP11 Polyclonal Antibody (HW368014)

Name: Anti-Human USP11 Polyclonal Antibody
Brand: abinScience
SKU: HW368014
Price: 96 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HW368014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human USP11 (Gly77-Asn292).

Target

Ubiquitin-specific-processing protease 11, Deubiquitinating enzyme 11, UHX1, USP11, Ubiquitin carboxyl-terminal hydrolase 11, Ubiquitin thioesterase 11

Purification

Purified by antigen affinity column.

Accession

P51784

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ubiquitin carboxyl-terminal hydrolase 11 (USP11) is a ~109 kDa protein. Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation.

1. Ideguchi, H. et al. (2002) The Biochemical journal 367, 87-95. PMID: 12084015

2. Schoenfeld, AR. et al. (2004) Molecular and cellular biology 24, 7444-55. PMID: 15314155

3. Yamaguchi, T. et al. (2007) The Journal of biological chemistry 282, 33943-8. PMID: 17897950

4. Sun, W. et al. (2010) Cellular signalling 22, 386-94. PMID: 19874889

5. Wiltshire, TD. et al. (2010) The Journal of biological chemistry 285, 14565-71. PMID: 20233726

6. Harper, S. et al. (2014) Biochemistry 53, 2966-78. PMID: 24724799

7. Wang, D. et al. (2018) Journal of molecular cell biology 10, 60-73. PMID: 28992046

Note

For research use only.

Images

References

Datasheet

Anti-Human USP11 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human USP11 Polyclonal Antibody (HW368014)

Overview

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References

Datasheet

SDS

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