Anti-Human USP19 Polyclonal Antibody (HF923014)

Name: Anti-Human USP19 Polyclonal Antibody
Brand: abinScience
SKU: HF923014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HF923014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human USP19 (Lys286-Gln376).

Target

Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, KIAA0891, ZMYND9, Ubiquitin carboxyl-terminal hydrolase 19, Ubiquitin-specific-processing protease 19, Zinc finger MYND domain-containing protein 9, USP19

Purification

Purified by antigen affinity column.

Accession

O94966

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a ~145 kDa protein. Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.

1. Hassink, GC. et al. (2009) EMBO reports 10, 755-61. PMID: 19465887

2. Lee, JG. et al. (2014) The Journal of biological chemistry 289, 3510-7. PMID: 24356957

3. Mei, Y. et al. (2011) The Journal of biological chemistry 286, 35380-35387. PMID: 21849505

4. Altun, M. et al. (2012) The Journal of biological chemistry 287, 1962-9. PMID: 22128162

5. Chai, P. et al. (2021) The Journal of cell biology 220. PMID: 33978709

6. Yu, W. et al. (2024) Journal of Alzheimer's disease : JAD 100, 799-808. PMID: 38943386

7. Lei, CQ. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 259-268. PMID: 31127032

8. Xue, W. et al. (2020) The Biochemical journal 477, 4295-4312. PMID: 33094816

Note

For research use only.

Images

References

Datasheet

Anti-Human USP19 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human USP19 Polyclonal Antibody (HF923014)

Overview

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References

Datasheet

SDS

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