Anti-Human USP2 Polyclonal Antibody (HF546014)

Name: Anti-Human USP2 Polyclonal Antibody
Brand: abinScience
SKU: HF546014
Price: 96 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HF546014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human USP2 (Thr275-Met605).

Target

Ubiquitin thioesterase 2, 41 kDa ubiquitin-specific protease, UBP41, Ubiquitin carboxyl-terminal hydrolase 2, Deubiquitinating enzyme 2, USP2, Ubiquitin-specific-processing protease 2

Purification

Purified by antigen affinity column.

Accession

O75604

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ubiquitin carboxyl-terminal hydrolase 2 (USP2) is a ~68 kDa protein. Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4.

1. Stevenson, LF. et al. (2007) The EMBO journal 26, 976-86. PMID: 17290220

2. Allende-Vega, N. et al. (2010) Oncogene 29, 432-41. PMID: 19838211

3. Shan, J. et al. (2009) Molecular cell 36, 469-76. PMID: 19917254

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-USP2 polyclonal antibody at 1μg/ml on various samples.
Lane 1: NIH3T3 cell lysate

References

Datasheet

Anti-Human USP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human USP2 Polyclonal Antibody (HF546014)

Overview

Images

References

Datasheet

SDS

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