Anti-Human USP20 Polyclonal Antibody (HP057014)

Name: Anti-Human USP20 Polyclonal Antibody
Brand: abinScience
SKU: HP057014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP057014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human USP20 (Ser781-Val914).

Target

LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20

Purification

Purified by antigen affinity column.

Accession

Q9Y2K6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ubiquitin carboxyl-terminal hydrolase 20 (USP20) is a ~102 kDa protein. Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability.

1. Zhang, M. et al. (2016) Cell research 26, 1302-1319. PMID: 27801882

2. Kim, JH. et al. (2018) EMBO reports 19. PMID: 29487085

3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314

4. Ha, J. et al. (2020) International journal of molecular sciences 21. PMID: 32354117

5. Berthouze, M. et al. (2009) The EMBO journal 28, 1684-96. PMID: 19424180

6. Li, Z. et al. (2005) EMBO reports 6, 373-8. PMID: 15776016

7. Feng, J. et al. (2022) Biochemical and biophysical research communications 593, 122-128. PMID: 35063767

Note

For research use only.

Images

References

Datasheet

Anti-Human USP20 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human USP20 Polyclonal Antibody (HP057014)

Overview

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References

Datasheet

SDS

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