Anti-Human VPS41 Polyclonal Antibody (HW488014)

Name: Anti-Human VPS41 Polyclonal Antibody
Brand: abinScience
SKU: HW488014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HW488014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human VPS41 (Lys31-Asp361).

Target

Vacuolar protein sorting-associated protein 41 homolog, VPS41, S53

Purification

Purified by antigen affinity column.

Accession

P49754

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Vacuolar protein sorting-associated protein 41 homolog (VPS41) is a ~98 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo.

1. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085

2. van der Welle, REN. et al. (2021) EMBO molecular medicine 13, e13258. PMID: 33851776

3. Pols, MS. et al. (2013) Traffic (Copenhagen, Denmark) 14, 219-32. PMID: 23167963

4. Lin, X. et al. (2014) Scientific reports 4, 7282. PMID: 25445562

5. Khatter, D. et al. (2015) Journal of cell science 128, 1746-61. PMID: 25908847

6. Radisky, DC. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 5662-6. PMID: 9159129

7. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203

8. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

9. Garg, S. et al. (2011) Immunity 35, 182-93. PMID: 21802320

Note

For research use only.

Images

References

Datasheet

Anti-Human VPS41 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human VPS41 Polyclonal Antibody (HW488014)

Overview

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Datasheet

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