Anti-Human WDR24 Polyclonal Antibody (HP377024)

Name: Anti-Human WDR24 Polyclonal Antibody
Brand: abinScience
SKU: HP377024
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP377024

Description

Anti-Human WDR24 Polyclonal Antibody (HP377024) is a rabbit polyclonal antibody detecting WDR24. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human WDR24 (Met21-Ala331).

Target

C16orf21, EC:2.3.2.27, GATOR2 complex protein WDR24, WD repeat-containing protein 24, WDR24

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q96S15

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

GATOR2 complex protein WDR24 is a ~88 kDa protein. Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex.

1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238

2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471

3. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190

4. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210

5. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510

6. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027

7. Dai, X. et al. (2023) Nature metabolism 5, 265-276. PMID: 36732624

Note

For research use only

Images

References

Datasheet

Anti-Human WDR24 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human WDR24 Polyclonal Antibody (HP377024)

Overview

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References

Datasheet

SDS

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