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Anti-Human YEATS2 Polyclonal Antibody (HP972014)

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Overview
Catalog No.HP972014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human YEATS2 (Asp196-Gly335).
Target YEATS2, KIAA1197, YEATS domain-containing protein 2
Purification Purified by antigen affinity column.
Accession Q9ULM3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

YEATS domain-containing protein 2 (YEATS2) is a ~150 kDa protein. Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.

1. Wang, YL. et al. (2008) The Journal of biological chemistry 283, 33808-15. PMID: 18838386
2. Guelman, S. et al. (2009) Molecular and cellular biology 29, 1176-88. PMID: 19103755
3. Zhao, D. et al. (2016) Cell research 26, 629-32. PMID: 27103431
Note For research use only.
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Formula
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V₁ (Stock Vol.)
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Anti-Human YEATS2 Polyclonal Antibody

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