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Anti-Human ZBTB48 Polyclonal Antibody (HY492014)

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Overview
Catalog No.HY492014
Description
Anti-Human ZBTB48 Polyclonal Antibody (HY492014) is a rabbit polyclonal antibody detecting ZBTB48 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human ZBTB48 (Val289-Leu628).
Target Telomere zinc finger-associated protein, TZAP, Krueppel-related zinc finger protein 3, hKR3, Zinc finger and BTB domain-containing protein 48, Zinc finger protein 855, ZBTB48, HKR3, TZAP, ZNF855
Purification Purified by antigen affinity column.
Accession P10074
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Zinc finger and BTB domain-containing protein 48 (ZBTB48) is a ~77 kDa protein. Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions.

1. Li, JS. et al. (2017) Science (New York, N.Y.) 355, 638-641. PMID: 28082411
2. Jahn, A. et al. (2017) EMBO reports 18, 929-946. PMID: 28500257
3. Yoon, JH. et al. (2014) The Journal of biological chemistry 289, 4018-31. PMID: 24382891
4. Sugawara, M. et al. (1994) Molecular and cellular biology 14, 8438-50. PMID: 7969177
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human ZBTB48 Polyclonal Antibody

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