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Anti-Human ZC3H4 Polyclonal Antibody (HP019014)

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Overview
Catalog No.HP019014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human ZC3H4 (Glu417-Gly503).
Target KIAA1064, C19orf7, ZC3H4, Zinc finger CCCH domain-containing protein 4
Purification Purified by antigen affinity column.
Accession Q9UPT8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Zinc finger CCCH domain-containing protein 4 (ZC3H4) is a ~140 kDa protein. RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs.

1. Austenaa, LMI. et al. (2021) Nature structural & molecular biology 28, 337-346. PMID: 33767452
2. Estell, C. et al. (2021) eLife 10. PMID: 33913806
Note For research use only.
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Formula
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Anti-Human ZC3H4 Polyclonal Antibody

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