Anti-Human ZFP36 Polyclonal Antibody (HB820014)

Name: Anti-Human ZFP36 Polyclonal Antibody
Brand: abinScience
SKU: HB820014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB820014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human ZFP36 (Thr106-Gly176).

Target

Zinc finger protein 36, RNF162A, TIS11A, Growth factor-inducible nuclear protein NUP475, Zfp-36, ZFP36, G0/G1 switch regulatory protein 24, G0S24, Tristetraprolin, NUP475, mRNA decay activator protein ZFP36, TTP

Purification

Purified by antigen affinity column.

Accession

P26651

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

mRNA decay activator protein ZFP36 is a ~34 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA.

1. Lai, WS. et al. (1999) Molecular and cellular biology 19, 4311-23. PMID: 10330172

2. Lai, WS. et al. (2000) The Journal of biological chemistry 275, 17827-37. PMID: 10751406

3. Lai, WS. et al. (2001) The Journal of biological chemistry 276, 23144-54. PMID: 11279239

4. Brooks, SA. et al. (2002) Arthritis and rheumatism 46, 1362-70. PMID: 12115244

5. Lai, WS. et al. (2003) Molecular and cellular biology 23, 3798-812. PMID: 12748283

6. Brooks, SA. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 7263-71. PMID: 15187101

7. Ogilvie, RL. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 953-61. PMID: 15634918

8. Marderosian, M. et al. (2006) Oncogene 25, 6277-90. PMID: 16702957

9. Lai, WS. et al. (2006) Molecular and cellular biology 26, 9196-208. PMID: 17030620

10. Kedar, VP. et al. (2010) PloS one 5, e9588. PMID: 20221403

Note

For research use only.

Images

References

Datasheet

Anti-Human ZFP36 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human ZFP36 Polyclonal Antibody (HB820014)

Overview

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