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Anti-IDO1 Polyclonal Antibody (HB992014)

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Overview
Catalog No.HB992014
Description
Anti-IDO1 Polyclonal Antibody (HB992014) is a rabbit polyclonal antibody detecting IDO1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human IDO1 (Met1-Gly403).
Target INDO, IDO1, Indoleamine-pyrrole 2, 3-dioxygenase, Indoleamine 2, 3-dioxygenase 1, IDO-1, IDO
Purification Purified by antigen affinity column.
Accession P14902
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Indoleamine 2,3-dioxygenase 1 (IDO1) is a ~45 kDa protein. Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan.

1. Metz, R. et al. (2007) Cancer research 67, 7082-7. PMID: 17671174
2. Yuasa, HJ. et al. (2007) Journal of molecular evolution 65, 705-14. PMID: 18026683
3. van Baren, N. et al. (2015) Frontiers in immunology 6, 34. PMID: 25691885
4. Uyttenhove, C. et al. (2003) Nature medicine 9, 1269-74. PMID: 14502282
5. Munn, DH. et al. (2013) Trends in immunology 34, 137-43. PMID: 23103127
6. Schmidt, SV. et al. (2014) Frontiers in immunology 5, 384. PMID: 25157255
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-IDO1 Polyclonal Antibody

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