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Anti-IGFBP2 Polyclonal Antibody (HB875014)

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Overview
Catalog No.HB875014
Description
Anti-IGFBP2 Polyclonal Antibody (HB875014) is a rabbit polyclonal antibody detecting IGFBP2 in ELISA, IHC, WB. Suitable for Human, Bovine, Ovis aries, and Pig.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human IGFBP2 (Ala36-Gln325).
Target BP2, IBP-2, IGFBP2, IGF-binding protein 2, Insulin-like growth factor-binding protein 2, IGFBP-2, IBP2
Purification Purified by antigen affinity column.
Accession P18065
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Insulin-like growth factor-binding protein 2 (IGFBP2) is a ~34 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury.

1. Rorive, S. et al. (2008) Glia 56, 1679-90. PMID: 18563800
2. Wang, X. et al. (2024) Apoptosis : an international journal on programmed cell death 29, 1109-1125. PMID: 38796567
3. Shen, X. et al. (2012) Molecular and cellular biology 32, 4116-30. PMID: 22869525
4. Wang, GK. et al. (2006) The Journal of biological chemistry 281, 14085-91. PMID: 16569642
5. Feng, N. et al. (2015) Journal of molecular neuroscience : MN 57, 426-34. PMID: 26076738
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-IGFBP2 Polyclonal Antibody

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