Anti-IL-13 Polyclonal Antibody (HW632014)

Name: Anti-IL-13 Polyclonal Antibody
Brand: abinScience
SKU: HW632014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
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Overview

Catalog No.

HW632014

Description

Anti-IL13 Polyclonal Antibody (HW632014) is a rabbit polyclonal antibody detecting IL13 in ELISA, IHC, WB. Suitable for Human, Macaca mulatta, Macaca thibetana, and Pan troglodytes.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IL13 (Pro36-Asn146).

Target

IL13, NC30, Interleukin-13, IL-13

Purification

Purified by antigen affinity column.

Accession

P35225

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-13 (IL13) is a ~15 kDa protein. Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells. Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1. Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B.

1. Minty, A. et al. (1993) Nature 362, 248-50. PMID: 8096327

2. McKenzie, AN. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 3735-9. PMID: 8097324

3. Defrance, T. et al. (1994) The Journal of experimental medicine 179, 135-43. PMID: 7903680

4. Luttmann, W. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 157, 1678-83. PMID: 8759755

5. Schnyder, B. et al. (1996) Blood 87, 4286-95. PMID: 8639787

6. Miloux, B. et al. (1997) FEBS letters 401, 163-6. PMID: 9013879

7. Kasaian, MT. et al. (2011) Journal of immunology (Baltimore, Md. : 1950) 187, 561-9. PMID: 21622864

Note

For research use only.

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