

| Catalog No. | HC296014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human ILF3 (Tyr672-Tyr891). | ||||||||
| Target | ILF3, MPHOSPH4, DRBP76, TCP80, DRBF, Translational control protein 80, M-phase phosphoprotein 4, Nuclear factor associated with dsRNA, NF90, NFAR, MPP4, NF-AT-90, Double-stranded RNA-binding protein 76, Interleukin enhancer-binding factor 3, Nuclear factor of activated T-cells 90 kDa | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q12906 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Interleukin enhancer-binding factor 3 (ILF3) is a ~95 kDa protein. RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. 1. Li, X. et al. (2017) Molecular cell 67, 214-227.e7. PMID: 28625552 2. Tran, H. et al. (2004) Molecular cell 13, 101-11. PMID: 14731398 3. Harashima, A. et al. (2010) Genes & development 24, 2640-53. PMID: 21123651 4. Dou, S. et al. (2021) eLife 10. PMID: 34110282 | ||||||||
| Note | For research use only. |
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