Anti-IMPA1 Polyclonal Antibody (HA692014)

Name: Anti-IMPA1 Polyclonal Antibody
Brand: abinScience
SKU: HA692014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA692014

Description

Anti-IMPA1 Polyclonal Antibody (HA692014) is a rabbit polyclonal antibody detecting Inositol monophosphatase 1; IMP 1; IMPase 1; 3.1.3.25; D-galactose 1-phosphate phosphatase; 3.1.3.94; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; IMPA1; IMPA in ELISA, IHC, WB. Suitable for Human, Bovine, Mouse, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant human IMPA1 (Met1-Asp277).

Target

Inositol monophosphatase 1; IMP 1; IMPase 1; 3.1.3.25; D-galactose 1-phosphate phosphatase; 3.1.3.94; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; IMPA1; IMPA

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P29218, P20456, O55023, O77591

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Inositol monophosphatase 1 (IMPA1) is a ~30 kDa protein. Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder.

1. Ohnishi, T. et al. (2007) The Journal of biological chemistry 282, 637-46. PMID: 17068342

2. Ganzhorn, AJ. et al. (1996) Biochemistry 35, 10957-66. PMID: 8718889

3. Parthasarathy, R. et al. (1997) Brain research 778, 99-106. PMID: 9462881

4. Figueiredo, T. et al. (2016) Molecular psychiatry 21, 1125-9. PMID: 26416544

Note

For research use only

Images

References

Datasheet

Anti-IMPA1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-IMPA1 Polyclonal Antibody (HA692014)

Overview

Images

References

Datasheet

SDS