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Anti-IRF5 Polyclonal Antibody (HC523014)

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Overview
Catalog No.HC523014
Description
Anti-IRF5 Polyclonal Antibody (HC523014) is a rabbit polyclonal antibody detecting IRF5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human IRF5 (Glu232-Ala477).
Target IRF5, Interferon regulatory factor 5, IRF-5
Purification Purified by antigen affinity column.
Accession Q13568
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Interferon regulatory factor 5 (IRF5) is a ~56 kDa protein. Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.

1. Barnes, BJ. et al. (2001) The Journal of biological chemistry 276, 23382-90. PMID: 11303025
2. Schoenemeyer, A. et al. (2005) The Journal of biological chemistry 280, 17005-12. PMID: 15695821
3. Chang Foreman, HC. et al. (2012) PloS one 7, e33098. PMID: 22412986
4. Lopez-Pelaez, M. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 17432-7. PMID: 25326418
5. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612
6. Yin, X. et al. (2021) Cell reports 34, 108628. PMID: 33440148
Note For research use only.
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Datasheet
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Formula
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Anti-IRF5 Polyclonal Antibody

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