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Anti-IYD Polyclonal Antibody (HB478014)

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Overview
Catalog No.HB478014
Description
Anti-IYD Polyclonal Antibody (HB478014) is a rabbit polyclonal antibody detecting Iodotyrosine deiodinase 1; IYD-1; 1.21.1.1; Iodotyrosine dehalogenase 1; IYD; C6orf71; DEHAL1 in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, and Pig.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant human IYD (Tyr81-Val289).
Target Iodotyrosine deiodinase 1; IYD-1; 1.21.1.1; Iodotyrosine dehalogenase 1; IYD; C6orf71; DEHAL1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6PHW0, Q5BK17, Q9DCX8, Q6TA49
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Iodotyrosine deiodinase 1 (IYD) is a ~33 kDa protein. Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine.

1. Gnidehou, S. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1574-6. PMID: 15289438
2. Moreno, JC. et al. (2008) The New England journal of medicine 358, 1811-8. PMID: 18434651
3. Hu, J. et al. (2015) The Journal of biological chemistry 290, 590-600. PMID: 25395621
4. Ingavat, N. et al. (2017) Biochemistry 56, 1130-1139. PMID: 28157283
Note For research use only
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Datasheet
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Formula
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Anti-IYD Polyclonal Antibody

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