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Anti-KMO Polyclonal Antibody (HT083014)

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Overview
Catalog No.HT083014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human KMO (Met1-Glu366).
Target KMO, Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase
Purification Purified by antigen affinity column.
Accession O15229
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Kynurenine 3-monooxygenase (KMO) is a ~55 kDa protein. Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).

1. Amaral, M. et al. (2013) Nature 496, 382-5. PMID: 23575632
2. Mole, DJ. et al. (2016) Nature medicine 22, 202-9. PMID: 26752518
3. Hutchinson, JP. et al. (2017) Nature communications 8, 15827. PMID: 28604669
4. Gao, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 2036-2045. PMID: 29208702
5. Kim, HT. et al. (2018) Cell chemical biology 25, 426-438.e4. PMID: 29429898
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-KMO Polyclonal Antibody

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