Anti-MAPK11 Polyclonal Antibody (HS729014)

Name: Anti-MAPK11 Polyclonal Antibody
Brand: abinScience
SKU: HS729014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HS729014

Description

Anti-MAPK11 Polyclonal Antibody (HS729014) is a rabbit polyclonal antibody detecting MAPK11 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MAPK11 (Leu24-Phe308).

Target

MAP kinase 11, Mitogen-activated protein kinase p38 beta, MAPK 11, Mitogen-activated protein kinase 11, PRKM11, SAPK2B, Stress-activated protein kinase 2b, MAP kinase p38 beta, MAPK11, p38b, p38-2, SAPK2, SAPK2b

Purification

Purified by antigen affinity column.

Accession

Q15759

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Mitogen-activated protein kinase 11 (MAPK11) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.

1. Shi, Y. et al. (2002) Biological chemistry 383, 1519-36. PMID: 12452429

2. Cuadrado, A. et al. (2010) The Biochemical journal 429, 403-17. PMID: 20626350

3. Robinson, KS. et al. (2022) Science (New York, N.Y.) 377, 328-335. PMID: 35857590

4. Deak, M. et al. (1998) The EMBO journal 17, 4426-41. PMID: 9687510

5. Scheper, GC. et al. (2001) Molecular and cellular biology 21, 743-54. PMID: 11154262

Note

For research use only.

Images

References

Datasheet

Anti-MAPK11 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-MAPK11 Polyclonal Antibody (HS729014)

Overview

Images

References

Datasheet

SDS

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