Anti-MCTS1 Polyclonal Antibody (HV818014)

Name: Anti-MCTS1 Polyclonal Antibody
Brand: abinScience
SKU: HV818014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HV818014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human MCTS1 (Met1-Lys181).

Target

MCTS1, Multiple copies T-cell malignancies, MCT1, MCT-1, Malignant T-cell-amplified sequence 1

Purification

Purified by antigen affinity column.

Accession

Q9ULC4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Malignant T-cell-amplified sequence 1 (MCTS1) is a ~20 kDa protein. Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation.

1. Reinert, LS. et al. (2006) Cancer research 66, 8994-9001. PMID: 16982740

2. Skabkin, MA. et al. (2010) Genes & development 24, 1787-801. PMID: 20713520

3. Bohlen, J. et al. (2023) Cell 186, 5114-5134.e27. PMID: 37875108

4. Dierov, J. et al. (1999) Journal of cellular biochemistry 74, 544-50. PMID: 10440924

5. Herbert, GB. et al. (2001) Oncogene 20, 6777-83. PMID: 11709712

6. Shi, B. et al. (2003) Blood 102, 297-302. PMID: 12637315

7. Hsu, HL. et al. (2005) Oncogene 24, 4956-64. PMID: 15897892

Note

For research use only.

Images

References

Datasheet

Anti-MCTS1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-MCTS1 Polyclonal Antibody (HV818014)

Overview

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References

Datasheet

SDS

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