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Anti-Mouse ADGRV1 Polyclonal Antibody (MD632014)

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Overview
Catalog No.MD632014
Description
Anti-Mouse ADGRV1 Polyclonal Antibody (MD632014) is a rabbit polyclonal antibody detecting ADGRV1. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse ADGRV1 (Gly28-Asp386).
Target ADGRV1, ADGRV1 subunit alpha, ADGRV1 subunit beta, Adgrv1, Adhesion G-protein coupled receptor V1, EC:3.4.-.-, G-protein coupled receptor 98, Gpr98, Kiaa0686, MASS1, Mass1, Monogenic audiogenic seizure susceptibility protein 1, Neurepin, Protein rueda, VLGR1, VLGR1 subunit beta, Vbeta, Very large G-protein coupled receptor 1, Vlgr1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8VHN7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Adhesion G-protein coupled receptor V1 (ADGRV1) is a ~687 kDa protein. G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.

1. McGee, J. et al. (2006) The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 6543-53. PMID: 16775142
2. Michalski, N. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 6478-88. PMID: 17567809
3. Yang, J. et al. (2010) PLoS genetics 6, e1000955. PMID: 20502675
4. Shin, D. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 19101-6. PMID: 24191038
5. Hu, QX. et al. (2014) The Journal of biological chemistry 289, 24215-25. PMID: 24962568
Note For research use only
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Formula
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C₁ × V₁ = C₂ × V₂
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Mouse ADGRV1 Polyclonal Antibody

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