Anti-Mouse ANGPT2/Ang2 Polyclonal Antibody (MT073014)

Name: Anti-Mouse ANGPT2/Ang2 Polyclonal Antibody
Brand: abinScience
SKU: MT073014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MT073014

Species reactivity

Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse ANGPT2/Ang2 (Asp283-Phe496).

Target

Angiopoietin-2 (ANG-2)

Purification

Purified by antigen affinity column.

Accession

O35608

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.

1. Morooka, N. et al. (2017) Circulation research 120, 1276-1288. PMID: 28179430

2. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Mouse ANGPT2/Ang2 polyclonal antibody at 1ug/mL on recombinant Mouse ANGPT2/Ang2 (Catalog No. MT073012).

References

Datasheet

Anti-Mouse ANGPT2/Ang2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse ANGPT2/Ang2 Polyclonal Antibody (MT073014)

Overview

Images

References

Datasheet

SDS

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