Anti-Mouse CD126/IL6R/IL-6RA Polyclonal Antibody (MY583014)

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Overview
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Datasheet

Overview

Catalog No.

MY583014

Description

Anti-Mouse CD126/IL6R/IL-6RA Polyclonal Antibody (MY583014) is a rabbit polyclonal antibody detecting IL-6RA in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD126/IL6R/IL-6RA (Gly33-Thr310).

Target

Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, CD126, Soluble interleukin-6 receptor subunit alpha, sIL6R, Il6ra, Il6r

Purification

Purified by antigen affinity column.

Accession

P22272

RRID

Anti-Mouse CD126/IL6R/IL-6RA Polyclonal Antibody (abinScience Cat# MY583014, RRID:AB_3724706)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-6 receptor subunit alpha (CD126/IL6R) is a ~50 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.

Note

For research use only.

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References

Datasheet