Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014)

Name: Anti-Mouse NKG2A/CD159a Polyclonal Antibody
Brand: abinScience
SKU: MB188014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

MB188014

Description

Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014) is a rabbit polyclonal antibody detecting NKG2A/CD159a in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Mouse CD159a/KLRC1 (Glu131-Ile244).

Target

Killer cell lectin-like receptor subfamily C, member 1, Natural killer cell protein group 2-A1, Natural killer cell receptor NKG2A, Klrc1, Nkg2a

Purification

Purified by antigen affinity column.

Accession

Q9Z202

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions.

1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576

2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229

3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220

4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650

5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520

6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206

7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984

8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742

9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301

Note

For research use only.

Images

References

Datasheet

Anti-Mouse NKG2A/CD159a Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014)

Overview

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References

Datasheet

SDS

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