Anti-Mouse CD191/CCR1 Polyclonal Antibody (MB896014)

Name: Anti-Mouse CD191/CCR1 Polyclonal Antibody
Brand: abinScience
SKU: MB896014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

MB896014

Description

Anti-Mouse CD191/CCR1 Polyclonal Antibody (MB896014) is a rabbit polyclonal antibody detecting C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant mouse CD191/CCR1 (Glu2-Ala34&Asp92-Lys107&Phe172-Arg197&Gln265-Leu281).

Target

C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P51675

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-C chemokine receptor type 1 (CD191/CCR1) is a ~40 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding.

1. Gao, JL. et al. (1997) The Journal of experimental medicine 185, 1959-68. PMID: 9166425

2. Ramos, CD. et al. (2005) Journal of leukocyte biology 78, 167-77. PMID: 15831559

3. Yan, J. et al. (2020) Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 17, 1170-1183. PMID: 31898284

Note

For research use only

Images

References

Datasheet

Anti-Mouse CD191/CCR1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Mouse CD191/CCR1 Polyclonal Antibody (MB896014)

Overview

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References

Datasheet

SDS

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